Mechanism of SNHG12 in Regulating Human Angiostatin Binding Protein Through MicroRNA-497 in the Migration and Invasion of Human Lung Cancer Cells

Objective: To investigate the effect of small nucleolar host gene 12 (SNHG12) on migration and invasion human lung cancer cells by regulating angiostatin binding protein through microribonucleic acid (microRNA)-497. Methods: A549, H1299, PC9 were cultured in Roswell Park Memorial Institute (RPMI)-1640 medium containing 10% fetal bovine serum, bronchial epithelial (HBE) Dulbecco’s modified eagle (DMEM) serum. The incubator conditions as follows: saturated humidity, 37?, 5% carbon dioxide (CO2). Results: expressions HBE, 1.00 ± 0.02, 5.61 0.42, 3.78 0.29, 3.51 0.23, respectively. microRNA-497HBE, 0.13, 0.21 0.04, 0.35 0.05, 0.37 0.06, respectively, with P < 0.05. microRNA-497 expression cell apoptosis rate group + pcDNA3.1 significantly higher than those miR-NC group, whereas A value number lower miR-negative control (NC) Compared SNHG12 lower, higher, Conclusion: can inhibit microRNA-497.